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Multiple Choice

Which hormone is released from the posterior pituitary to promote water reabsorption in the kidneys?

Antidiuretic hormone (ADH), also called vasopressin, is released from the posterior pituitary and acts on the kidneys to conserve water. It binds to V2 receptors on the principal cells of the collecting ducts, prompting the insertion of aquaporin-2 water channels into the apical membrane. This increases water permeability, so more water is reabsorbed back into the bloodstream, concentrating the urine and reducing urine volume. ADH release is triggered by high plasma osmolality or low blood volume, and the posterior pituitary stores ADH produced by hypothalamic neurons. The other hormones—TSH, GH, and ACTH—are from the anterior pituitary and regulate thyroid function, growth/metabolism, and adrenal cortex activity, not direct renal water reabsorption.

Antidiuretic hormone (ADH), also called vasopressin, is released from the posterior pituitary and acts on the kidneys to conserve water. It binds to V2 receptors on the principal cells of the collecting ducts, prompting the insertion of aquaporin-2 water channels into the apical membrane. This increases water permeability, so more water is reabsorbed back into the bloodstream, concentrating the urine and reducing urine volume. ADH release is triggered by high plasma osmolality or low blood volume, and the posterior pituitary stores ADH produced by hypothalamic neurons. The other hormones—TSH, GH, and ACTH—are from the anterior pituitary and regulate thyroid function, growth/metabolism, and adrenal cortex activity, not direct renal water reabsorption.